Advanced approach to longevity and preventive health

Our 3D Anti-Aging Science™ targets the three pillars of aging by detoxifying blood of inflammatory proteins, defending wellness through immune optimization, and delivering vitality and regeneration at the cellular-level.

3D Anti-Aging Science™

The 3D Anti-Aging Science™ program combines advanced medical evaluations with personalized treatment planning to help patients explore longevity-focused strategies based on their health goals, medical history, and clinical suitability.

Detox inflammation with Therapeutic Plasma Exchange

Therapeutic Plasma Exchange (TPE) is the first pillar of the 3D Anti-Aging Science™ program. This advanced therapy is designed to help filter chronic inflammatory markers, spike proteins, autoimmune factors, cholesterolmicroplastics, heavy metals, viruses, bacteria, and cellular waste from the bloodstream.

By cleansing one’s plasma, TPE may help support overall wellness, inflammation management, and reduced brain fog.

Key Benefits

Defend immunity with Natural Killer Cell Therapy

Natural Killer (NK) Cell Therapy is designed to strengthen the body’s immune defense by enhancing its ability to identify and target compromised, aging, or dysfunctional cells that may contribute to inflammation and cellular decline.

As the second pillar of the 3D Anti-Aging Science™ program, this therapy supports immune surveillance, cellular cleanup, and long-term vitality as part of a personalized, physician-guided longevity strategy.

Key Benefits

Enhances targeted immune surveillance
Supports the clearance of senescent and dysfunctional cells
Strengthens antiviral immune defense
Supports a healthier environment for regenerative therapies
Promotes long-term wellness and vitality

Deliver vitality with Stem Cell & Exosome Replenishment

As part of the 3D Anti-Aging Science™ program, Stem Cell & Exosome Replenishment is designed to support deep cellular repair, helping damaged tissues recover, regenerate, and restore healthier function.

This regenerative approach may help reduce chronic inflammation, support mobility, skin quality, injury recovery, general vitality, and create a stronger foundation for long-term wellness. Each protocol is personalized based on medical evaluation, physician assessment, and clinical suitability.

Key Benefits

Activates cellular repair and regeneration
May help quiet chronic inflammation
Supports skin, joints, and physical function
May enhance recovery, energy, and vitality
Part of a physician-guided regenerative plan

About Proactive Longevity

Founded in 2018, Proactive Longevity was created with the mission of bringing advanced longevity, regenerative medicine, and health optimization strategies to North America.

Through partnerships with leading physicians, laboratories, and healthcare innovators, the organization has developed a comprehensive approach focused on helping patients take a more proactive role in their long-term health and wellness.

Today, Proactive Longevity operates facilities in Beverly Hills and Malibu, California and Cabo San Lucas, Mexico. Its Cabo facility is among the few clinics in Mexico to receive regulatory approval for regenerative medicine services, while the Beverly Hills location provides advanced longevity-focused evaluations and Therapeutic Plasma Exchange as part of the 3D Anti-Aging Science™ program.

Meet the experts behind Proactive Longevity

Dr. John Layke

Chief Medical Officer | Co-Founder

Dr. Layke is a double board-certified Plastic and Reconstructive Surgeon certified by both the American Board of Surgery and the American Board of Plastic Surgery. In addition to co-founding Beverly Hills Plastic Surgery Group, he has been involved in multiple regenerative medicine and longevity initiatives, combining advanced aesthetic medicine with innovative wellness strategies.

As Chief Medical Officer of Proactive Longevity, Dr. Layke helps lead the development of physician-guided programs focused on longevity, health optimization, and personalized patient care.

Dr. Payman Danielpour

Co-Founder

Dr. Danielpour is a highly respected board-certified Plastic and Reconstructive Surgeon recognized for his expertise in aesthetic surgery and innovative treatment approaches. He completed his medical training at The Chicago Medical School and received advanced surgical training through one of the nation’s most established plastic surgery programs.

As a co-founder of the Beverly Hills Plastic Surgery Group and of Proactive Longevity, Dr. Danielpour brings decades of clinical experience and a patient-centered philosophy focused on helping individuals pursue long-term health, wellness, and vitality. Additionally, Dr. Danielpour is the co-host of the “Forever Young” podcast, where he explores the intersection of beauty, health, performance, and aging alongside leading experts and innovators.

Dr. Joseph Loewenbein

Chief Medical Officer | Co-Founder

Dr. Loewenbein is a board-certified anesthesiologist with more than two decades of clinical experience. His work in pain management, neuroscience, and regenerative medicine has led him to explore innovative approaches aimed at improving healthspan and quality of life.

As a co-founder of Proactive Longevity, Dr. Loewenbein plays a key role in advancing the organization’s commitment to bringing emerging longevity and regenerative medicine technologies to patients seeking a more proactive approach to aging and wellness.

Sports Longevity

Our Sports Optimization team has worked with numerous professional and collegiate athletes to restore or enhance tissues, joints, and organs that have been damaged or lost due to disease, injury, repetition, or aging.

Schedule a Personalized Consultation

Fill out the form below to request your complimentary consultation.

A member of our team will contact you to discuss your goals, answer your questions, and help determine the next steps. Every treatment plan is customized based on physician evaluation, medical history, and clinical suitability.

Our Locations

The 3D Anti-Aging Science™ program is delivered across our facilities in Beverly Hills and MalibuCalifornia clinics, as well as our flagship location in Cabo San Lucas, Mexico.

Consultations, physician evaluations, treatment planning, and Therapeutic Plasma Exchange (TPE) are performed in Beverly Hills and Malibu.

For eligible patients, advanced regenerative medicine therapies may be incorporated into their personalized treatment plan in Cabo San Lucas (Mexico).

Frequently Asked
Questions

What is the 3D Anti-Aging Science™ program?

Our 3D Anti-Aging Science™ protocol is a comprehensive, multi-layered therapeutic framework designed to optimize human longevity and biological performance from the inside out. The system operates across three distinct clinical lanes—Detox, Defend, and Deliver—to systematically cleanse, protect, and revitalize the body at a cellular level. The process begins by flushing out years of chronic systemic inflammation, metabolic waste, and circulating autoantibodies through advanced filtration modalities like Therapeutic Plasma Exchange (TPE) to establish a pristine internal slate. From there, the protocol transitions into proactive defense and cellular delivery, utilizing precision diagnostics, targeted cellular infusions, and advanced biohacking modalities to restore optimal signaling pathways, rebuild immune resilience, and pour vital biological capital back into the tissue. By bridging cutting-edge biotechnology with luxury concierge medicine, this signature framework provides elite athletes and high-performance individuals with a scalable, science-backed blueprint to lower their biological age and maintain peak vitality over a lifetime.

Who may be a candidate for the program?

Many participants are adults seeking a more proactive approach to healthy aging, wellness, and long-term health optimization. Eligibility for specific therapies and services is determined through physician evaluation, medical history review, and clinical suitability.

Are all treatments performed in Beverly Hills?

Exchange (TPE) are performed in Beverly Hills and Malibu. Certain regenerative medicine therapies may be available at our Cabo San Lucas facility for patients who are clinically eligible.

What happens during the consultation?

Your consultation includes a discussion of your health goals, medical history, and overall wellness objectives. Our team will help determine whether additional evaluations or components of the 3D Anti-Aging Science™ program may be appropriate for you.

Is every patient recommended the same treatment plan?

No. Every treatment plan is individualized. Recommendations are based on physician evaluation, biomarker analysis, health goals, medical history, and clinical suitability.

How do I get started?

The first step is scheduling a consultation with our team. From there, we can discuss your goals, answer your questions, and determine the most appropriate next steps for your personalized longevity plan.